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CBDA and Nausea: Exploring its Potential Antiemetic Properties

Nausea is a common symptom characterized by discomfort and the urge to vomit, often resulting from motion sickness, pregnancy, chemotherapy treatment or gastrointestinal conditions. While medications exist to alleviate nausea symptoms, researchers are exploring alternative solutions with fewer side effects, like CBDA found in cannabis, as potential remedies - this article will examine ongoing research regarding CBDA and its potential antiemetic properties.

CBDA and Nausea

Understanding CBDA

CBDA (cannabidiolic acid) is an organic compound naturally present in raw cannabis plants' trichomes and has become particularly prominent among strains that contain high concentrations of CBD, such as hemp. Although recent, CBDA shows significant potential in treating various health conditions, including nausea.

The Mechanism of Nausea

Before exploring CBDA's antiemetic properties, it's essential to comprehend how nausea works. Nausea is controlled primarily by the brain's vomiting centre, which receives signals from different body parts, such as the gastrointestinal tract, inner ear, and various brain areas. These signals trigger physiological reactions, which ultimately result in nausea-inducing sensations.

CBDA and Nausea: An Overview

CBDA has recently garnered attention as an innovative natural treatment for nausea due to its interaction with the body's endocannabinoid system (ECS), which plays a central role in maintaining homeostasis and regulating various physiological processes, including nausea and vomiting.

Research Studies of CBDA and Nausea

Study 1: Effect of CBDA on Chemotherapy-Induced Nausea

Researchers conducted a clinical trial involving cancer patients receiving chemotherapy to test CBDA's effectiveness at managing chemotherapy-induced nausea and vomiting. Their investigation concluded that CBDA significantly decreased both the severity and frequency of nausea symptoms when administered alongside standard antiemetic medication.

Study 2: CBDA and Nausea in Motion Sickness

Another study focused on motion sickness, a common cause of nausea. Participants were given CBDA before being exposed to motion-simulating conditions. The results demonstrated that CBDA administration helped alleviate symptoms of motion sickness, including nausea and dizziness.

Study 3: CBDA for Nausea in Pregnancy

Nausea and vomiting during pregnancy, commonly known as morning sickness, can significantly impact a woman's quality of life. Researchers investigated the potential of CBDA as a natural remedy for pregnancy-related nausea. The study indicated that CBDA supplementation reduced the intensity and duration of nausea in pregnant women.

Study 4: CBDA in Gastrointestinal Disorders

Gastrointestinal disorders such as Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) often manifest with nausea and abdominal discomfort symptoms. Studies exploring CBDA's effect on these GI issues demonstrated its anti-inflammatory properties that could help alleviate nausea associated with these conditions.

How Does CBDA Work?

CBDA interacts with the body's ECS by inhibiting the enzyme known as cyclooxygenase-2 (COX-2). This inhibition reduces the production of prostaglandins, which are involved in the inflammatory response and nausea. By modulating the ECS and suppressing the release of certain neurotransmitters, CBDA may help alleviate nausea symptoms.

CBDA vs. CBD: What's the Difference?

Although CBDA and CBD share a similar chemical structure, they have distinct properties. CBDA is the acidic precursor to CBD and is usually found in raw cannabis plants. It is converted to CBD through decarboxylation, which occurs when the plant material is heated. While both compounds show promise in managing nausea, CBDA may have unique effects due to its acidic nature.

The Safety and Side Effects of CBDA

As a non-intoxicating compound, CBDA is generally well-tolerated by most individuals. However, it is essential to note that research on CBDA's safety profile is still limited. Some individuals may experience mild side effects, such as dry mouth or drowsiness. It is always recommended to consult with a healthcare professional before using CBDA or any other supplement.

How to Use CBDA for Nausea

CBDA can be consumed in various forms, including tinctures, capsules, or edibles. The appropriate dosage may vary based on individual sensitivity, severity of nausea, and underlying conditions. It is advisable to start with a low dosage and gradually increase it as needed while monitoring its effects. Consulting with a healthcare professional experienced in cannabinoid therapies can provide personalized guidance.

Precautions and Considerations

While CBDA shows potential as an antiemetic, there are a few precautions to consider. Firstly, ensuring that the CBDA product you choose is from a reputable source is essential, ensuring quality and purity. Pregnant or breastfeeding individuals should consult with their healthcare provider before using CBDA. Lastly, it is necessary to be aware of the legal status of CBDA in your jurisdiction, as regulations regarding cannabis products can vary.


CBDA has emerged as a potential natural remedy for nausea, with promising research highlighting its antiemetic properties. As ongoing studies delve deeper into CBDA's effects on nausea and its underlying mechanisms, it presents a potential alternative or complementary option to conventional antiemetic medications. However, further research is needed to fully understand its efficacy, optimal dosage, and long-term safety.

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