Appearance: Clear or white crystalline powder
Odor: No significant odor
Flavor: No significant flavor
Consistency: Fine-coarse powdered crystal
Solubility: Soluble with oils
Composition: 100% hemp extract by weight
Plant Parts Used in Oil: Whole plant
(flowers, leaves, stems, stalks, seeds)
CBD Isolate
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According to The National Library of Medicine:
Several studies suggest that THC and CBD may exert opposite actions on brain function and psychopathology [188], possibly in relation to the action of CBD as a potent CB1 receptor antagonist/inverse agonist [21] (see above). Several lines of preclinical work have shown that CBD reduces the effects of THC on several behavioral functions [189-191]. In line with these data, CBD has been found to reduce the anxiety and improve the sensation of well being induced by an acute, high THC dose in healthy volunteers [192].
In contrast with these data, a number of studies have shown that CBD pretreatment potentiated the behavioral effects induced by THC [193-195]. These actions may signify the ability of CBD to inhibit cytochrome P450-mediated drug metabolism [196,197], which may increase THC blood and brain concentrations [193,195].
Notably, the behavioral outcomes of CBD do not appear to be only due to potential pharmacodynamic/pharmacokynetic competition with THC; indeed, recent studies have shown that CBD exerts inherent anxiolytic effects, both in rodent models [157,198-201] and, more recently, in patients affected by social phobia [202,203]. The anxiolytic action of CBD may be linked to 5-HT1A receptor, but not through benzodiazepine receptors [204]. Of note, the anxiolytic action of CBD also appears to be bidirectional, as only low to moderate doses, but not high doses, have been associated with exert anxiolytic effects [200,205].
The anxiolytic action of CBD do not appear to be mediated by benzodiazepine receptors [204], but rather by 5-HT1A serotonin receptors in the bed nucleus of the stria terminalis [206], a critical component of the amygdaloid complex involved in the regulation of stress response.
Accordingly, CBD has been shown to reduce amygdalar responses to fearful stimuli [207]; this mechanism may be essential for the anxiolytic effects of this compound in social phobia [203]. Furthermore, CBD has been shown to elicit antipanic effects through the activation of 5-HT1A receptors in the dorsal periaqueductal gray, a critical area for the modulation of emotional reactivity to stress [208,209].